|
KMID : 0363219980360040688
|
|
Korean Journal of Dermatology
1998 Volume.36 No. 4 p.688 ~ p.693
|
|
|
A Case of CD3O-negative Large T-Cell Lymphoma Showing p53 and mdm-2 Expression
|
|
Ro Young-Suck
Park Chan-Kum
|
|
|
Abstract
|
|
|
Primary cutaneous large cell lymphomas of the T-cell phenotype are relatively uncommon. Previous studies have revealed the following prognostic variables: the distribution of skin lesions, a history of pre-existing mycosis fungoides, CD30(Ki-1) antigen positivity and anaplastic morphology. CD30 antigen positivity has been associated with an indolent clinical course, in contrast to CD30-negative cases. However, a recent study revealed that multicentric skin lesions confer a worse prognosis on this subgroup of patients rather than the absence of CD30 antigen. p53 immunoreactivity also
has been reported to be associated with high grade non-Hodgkin’s lymphoma, although it is relatively uncommon.
Herein, we report a case of a patient with EBV-related, CD30-negative primary cutaneous large cell lymphoma of the T-cell phenotype showing p53 and mdm-2 expression. She was initially diagnosed as having a benign-looking deep folliculitis or furunculosis, but treated successfully with radiation therapy without recurrence up to now.
|
|
|
KEYWORD
|
|
|
CD30(Ki-1)-negative, Large cell lymphoma, p53, mdm-2,
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|